| home Thursday, October 27 | Rock The John | Littlejohn Coliseum | 7:30 PM | | |
| home Monday, November 07 | Gardner-Webb | Clemson, S.C. (Littlejohn Coliseum) | 11:00 AM | W, 81 - 54 | |
| home Thursday, November 10 | Wofford | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | W, 79 - 68 | |
| home Sunday, November 13 | Richmond | Clemson, S.C. (Littlejohn Coliseum) | 2:00 PM | W, 61 - 40 | |
| home Thursday, November 17 | South Carolina | Clemson, S.C. (Littlejohn Coliseum) | 6:00 PM | L, 31 - 85 | |
| neutral Thursday, November 24 | Kansas State | St. Thomas, U.S.V.I. | 8:00 PM | L, 38 - 76 | |
| neutral Friday, November 25 | Arkansas | St. Thomas, U.S.V.I. | 8:00 PM | L, 62 - 76 | |
| neutral Saturday, November 26 | Northern Arizona | St. Thomas, U.S.V.I. | 5:45 PM | W, 80 - 62 | |
| away Thursday, December 01 | Charleston Southern | Charleston, S.C. | 6:00 PM | W, 84 - 31 | |
| away Sunday, December 04 | Georgia State | Atlanta, Ga. | 2:00 PM | W, 85 - 58 | |
| home Thursday, December 08 | Charlotte | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | W, 79 - 54 | |
| home Saturday, December 10 | Western Carolina | Clemson, S.C. (Littlejohn Coliseum) | 2:00 PM | W, 81 - 42 | |
| away Sunday, December 18 | NC State * | Raleigh, N.C. | 6:00 PM | L, 59 - 77 | |
| home Tuesday, December 20 | Radford | Clemson, S.C. (Littlejohn Coliseum) | 1:00 PM | W, 81 - 38 | |
| home Thursday, December 29 | Virginia Tech * | Clemson, S.C. (Littlejohn Coliseum) | 6:00 PM | W, 64 - 59 | |
| home Sunday, January 01 | Wake Forest * | Clemson, S.C. (Littlejohn Coliseum) | 2:00 PM | W, 60 - 59 | |
| away Thursday, January 05 | Florida State * | Tallahassee, Fla. | 6:00 PM | L, 62 - 93 | |
| home Sunday, January 08 | Syracuse * | Clemson, S.C. (Littlejohn Coliseum) | 2:00 PM | L, 77 - 91 | |
| away Thursday, January 12 | Duke * | Durham, N.C. | 7:00 PM | L, 56 - 66 | |
| away Sunday, January 15 | Pitt * | Pittsburgh, Pa. | 2:00 PM | W, 72 - 57 | |
| home Thursday, January 19 | Notre Dame * | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | L, 54 - 57 | |
| away Sunday, January 22 | Boston College * | Chestnut Hill, Mass. | 2:00 PM | W, 67 - 57 | |
| away Thursday, January 26 | Georgia Tech * | Atlanta, Ga. | 7:00 PM | L, 74 - 85 | |
| home Sunday, January 29 | North Carolina * | Clemson, S.C. (Littlejohn Coliseum) | 4:00 PM | L, 58 - 69 | |
| home Thursday, February 02 | Miami * | Clemson, S.C. (Littlejohn Coliseum) | 8:00 PM | L (OT), 66 - 69 | |
| away Sunday, February 05 | Wake Forest * | Winston-Salem, N.C. | 4:00 PM | L (OT), 64 - 69 | |
| home Thursday, February 09 | Georgia Tech * | Clemson, S.C. (Littlejohn Coliseum) | 8:00 PM | W, 57-41 | |
| away Sunday, February 12 | Louisville * | Louisville, Ky. | 2:00 PM | L, 69 - 81 | |
| away Thursday, February 16 | Miami * | Coral Gables, Fla. | 6:00 PM | L, 54 - 59 | |
| home Thursday, February 23 | Virginia * | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | W, 79 - 69 | |
| home Sunday, February 26 | Florida State * | Clemson, S.C. (Littlejohn Coliseum) | 2:00 PM | W, 74 - 61 | |
| neutral Wednesday, March 01 | No. 15 Pitt | Greensboro, N.C. | 3:30 PM | W, 71 - 53 | |
| neutral Thursday, March 02 | No. 7 North Carolina | Greensboro, N.C. | 6:00 PM | L, 58 - 68 | |
| home Thursday, March 16 | High Point | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | W, 66 - 46 | |
| home Monday, March 20 | Auburn | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | W, 56 - 55 | |
| home Thursday, March 23 | Florida | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | L, 63 - 73 | |
