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  • Georgia Southwestern State (Exhibition)
    vs.
    clemson
    Monday, November 01
    Littlejohn Coliseum (home)
  • Presbyterian
    vs.
    clemson
    Tuesday, November 09
    Littlejohn Coliseum (home)
  • Wofford
    vs.
    clemson
    Friday, November 12
    Littlejohn Coliseum (home)
  • Bryant
    vs.
    clemson
    Monday, November 15
    Littlejohn Coliseum (home)
  • clemson
    vs.
    Temple
    Thursday, November 18
    Charleston, S.C. (TD Arena) (neutral)
    2021 Shriners Children's Charleston Classic
  • clemson
    vs.
    St. Bonaventure
    Friday, November 19
    Charleston, S.C. (TD Arena) (neutral)
    2021 Shriners Children's Charleston Classic
  • clemson
    vs.
    West Virginia
    Sunday, November 21
    Charleston, S.C. (TD Arena) (neutral)
    2021 Shriners Children's Charleston Classic
  • Charleston Southern
    vs.
    clemson
    Friday, November 26
    Littlejohn Coliseum (home)
  • clemson
    vs.
    Rutgers
    Tuesday, November 30
    Piscataway, N.J. (Jersey Mikes Arena) (away)
    ACC/Big Ten Challenge
  • clemson
    vs.
    Miami *
    Saturday, December 04
    Coral Gables, Fla. (Watsco Center) (away)
  • clemson
    vs.
    Drake
    Saturday, December 11
    Atlanta, Ga. (State Farm Arena) (neutral)
    2021 Holiday Hoopsgiving
  • Miami (Ohio)
    vs.
    clemson
    Tuesday, December 14
    Littlejohn Coliseum (home)
  • South Carolina
    vs.
    clemson
    Saturday, December 18
    Littlejohn Coliseum (home)
  • clemson
    vs.
    Virginia *
    Wednesday, December 22
    Charlottesville, Va. (John Paul Jones Arena) (away)
  • Duke *
    vs.
    clemson
    Wednesday, December 29
    Littlejohn Coliseum (home)
  • Virginia *
    vs.
    clemson
    Tuesday, January 04
    Littlejohn Coliseum (home)
  • clemson
    vs.
    NC State *
    Saturday, January 08
    Raleigh, N.C. (PNC Arena) (away)
  • clemson
    vs.
    Notre Dame *
    Wednesday, January 12
    Notre Dame, Ind. (Joyce Center) (away)
  • Boston College *
    vs.
    clemson
    Saturday, January 15
    Littlejohn Coliseum (home)
  • clemson
    vs.
    Syracuse *
    Tuesday, January 18
    Syracuse, N.Y. (Carrier Dome) (away)
  • Pittsburgh *
    vs.
    clemson
    Saturday, January 22
    Littlejohn Coliseum (home)
  • clemson
    vs.
    Duke *
    Tuesday, January 25
    Durham, N.C. (Cameron Indoor Stadium) (away)
  • Florida State *
    vs.
    clemson
    Wednesday, February 02
    Littlejohn Coliseum (home)
  • clemson
    vs.
    Georgia Tech *
    Saturday, February 05
    Atlanta, Ga. (McCamish Pavilion) (away)
  • North Carolina *
    vs.
    clemson
    Tuesday, February 08
    Littlejohn Coliseum (home)
  • Notre Dame *
    vs.
    clemson
    Saturday, February 12
    Littlejohn Coliseum (home)
  • clemson
    vs.
    Florida State *
    Tuesday, February 15
    Tallahassee, Fla. (Donald L. Tucker Civic Center) (away)
  • clemson
    vs.
    Louisville *
    Saturday, February 19
    Louisville, Ky. (KFC Yum! Center) (away)
  • Wake Forest *
    vs.
    clemson
    Wednesday, February 23
    Littlejohn Coliseum (home)
  • clemson
    vs.
    Boston College *
    Saturday, February 26
    Chestnut Hill, Mass. (Conte Forum) (away)
  • Georgia Tech *
    vs.
    clemson
    Wednesday, March 02
    Littlejohn Coliseum (home)
  • Virginia Tech *
    vs.
    clemson
    Saturday, March 05
    Littlejohn Coliseum (home)
  • * Conference Games
  • All times listed are Eastern Time