| home Friday, November 11 | Georgia | Clemson, S.C. | 7:00 PM | W, 74 - 64 | |
| neutral Thursday, November 17 | Davidson | Orlando, Fla. | 11:00 AM | W, 95 - 78 | |
| neutral Friday, November 18 | Xavier | Orlando, Fla. | 1:30 PM | L, 77 - 83 | |
| neutral Sunday, November 20 | Oklahoma | Orlando, Fla. | 5:00 PM | L, 64 - 70 | |
| home Friday, November 25 | High Point | Clemson, S.C. | 7:00 PM | W, 83 - 74 | |
| home Wednesday, November 30 | Nebraska | Clemson, S.C. | 9:00 PM | W, 60 - 58 | |
| home Sunday, December 04 | Coppin State | Clemson, S.C. | 2:00 PM | W, 85 - 43 | |
| home Saturday, December 10 | Mercer | Clemson, S.C. | 4:00 PM | W, 90 - 47 | |
| home Tuesday, December 13 | SC State | Clemson, S.C. | 7:00 PM | W, 93 - 65 | |
| away Sunday, December 18 | Alabama | Birmingham, Ala. (Legacy Arena) | 4:00 PM | W, 67 - 54 | |
| away Wednesday, December 21 | South Carolina | Columbia, S.C. | 9:00 PM | W, 62 - 60 | |
| home Wednesday, December 28 | UNC Wilmington | Clemson, S.C. | 7:00 PM | W, 87 - 73 | |
| away Saturday, December 31 | Wake Forest * | Winston-Salem, N.C. | 12:00 PM | W, 73 - 68 | |
| home Tuesday, January 03 | North Carolina * | Clemson, S.C. | 7:00 PM | L, 86 - 89 | |
| away Saturday, January 07 | Notre Dame * | South Bend, Ind. | 3:00 PM | L, 70 - 75 | |
| away Thursday, January 12 | Georgia Tech * | Atlanta, Ga. | 7:00 PM | L, 63 - 75 | |
| home Saturday, January 14 | Virginia * | Clemson, S.C. | 12:00 PM | L, 73 - 77 | |
| away Thursday, January 19 | Louisville * | Louisville, Ky. | 9:00 PM | L, 60 - 92 | |
| home Sunday, January 22 | Virginia Tech * | Clemson, S.C. | 6:30 PM | L, 81 - 82 | |
| away Saturday, January 28 | Pittsburgh * | Pittsburgh, Pa. | 12:00 PM | W, 67 - 60 | |
| home Wednesday, February 01 | Georgia Tech * | Clemson, S.C. | 7:00 PM | W, 74 - 62 | |
| away Sunday, February 05 | Florida State * | Tallahassee, Fla. | 12:30 PM | L, 61 - 109 | |
| home Tuesday, February 07 | Syracuse * | Clemson, S.C. | 8:00 PM | L, 81 - 82 | |
| away Saturday, February 11 | Duke * | Durham, N.C. | 1:00 PM | L, 62 - 64 | |
| home Tuesday, February 14 | Wake Forest * | Clemson, S.C. | 7:00 PM | W, 95 - 83 | |
| away Saturday, February 18 | Miami * | Coral Gables, Fla. | 12:00 PM | L, 65 - 71 | |
| away Tuesday, February 21 | Virginia Tech * | Blacksburg, Va. | 7:00 PM | L, 70 - 71 | |
| home Saturday, February 25 | Florida State * | Clemson, S.C. | 12:00 PM | L, 74 - 76 | |
| home Wednesday, March 01 | NC State * | Clemson, S.C. | 8:00 PM | W, 78 - 74 | |
| home Saturday, March 04 | Boston College * | Clemson, S.C. | 4:00 PM | W, 82 - 68 | |
| neutral Tuesday, March 07 | NC State | Brooklyn, N.Y. | 12:00 PM | W, 75 - 61 | |
| neutral Wednesday, March 08 | Duke | Brooklyn, N.Y. | 2:00 PM | L, 72 - 79 | |
| home Tuesday, March 14 | Oakland | Clemson, S.C. | 8:00 PM | L, 69 - 74 | |
