| Date | OPPONENT | location | TIME | RESULTS | MEDIA |
|---|---|---|---|---|---|
| home Sunday, August 19 | Fan Appreciation Day | Clemson, SC | 3:00 PM | ||
| away Saturday, September 01 | Auburn - Chick-fil-A Kickoff Game | Georgia Dome - Atlanta, GA | 7:00 PM | W, 26 - 19 | |
| home Saturday, September 08 | Ball State (Youth Day) | Clemson, SC | 12:30 PM | W, 52 - 27 | |
| home Saturday, September 15 | Furman (Parents' Weekend) | Clemson, SC | 3:00 PM | W, 41 - 7 | |
| away Saturday, September 22 | Florida State * | Tallahassee, FL | 8:00 PM | L, 37 - 49 | |
| away Saturday, September 29 | Boston College * | Chestnut Hill, MA | 3:30 PM | W, 45 - 31 | |
| home Saturday, October 06 | Georgia Tech (Hall of Fame & Football Reunion Day) * | Clemson, SC | 3:30 PM | W, 47 - 31 | |
| home Saturday, October 20 | Virginia Tech (Military Appreciation Day) * | Clemson, SC | 12:00 PM | W, 38 - 17 | |
| away Thursday, October 25 | Wake Forest * | Winston-Salem, NC | 7:30 PM | W, 42 - 13 | |
| away Saturday, November 03 | Duke * | Durham, NC | 7:00 PM | W, 56 - 20 | |
| home Saturday, November 10 | Maryland (Homecoming) * | Clemson, SC | 3:30 PM | W, 45 - 10 | |
| home Saturday, November 17 | NC State (IPTAY Day) * | Clemson, SC | 3:30 PM | W, 62 - 48 | |
| home Saturday, November 24 | South Carolina (Solid Orange Day) | Clemson, SC | 7:00 PM | L, 17 - 27 | |
| neutral Monday, December 31 | LSU - Chick-fil-A Bowl | Georgia Dome - Atlanta, GA | 7:30 PM | W, 25 - 24 | |
| home Saturday, April 13 | 2013 Spring Game | Clemson, SC | 4:00 PM | ||
| * Conference Games | |||||
| All times listed are Eastern Standard Time | |||||
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