| home Monday, November 06 | Winthrop | Clemson, S.C. (Littlejohn Coliseum) | 11:00 AM | W, 71 - 41 | |
| home Friday, November 10 | Charleston Southern | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | W, 85 - 55 | |
| home Sunday, November 12 | Mercer | Clemson, S.C. (Littlejohn Coliseum) | 2:00 PM | W, 90 - 66 | |
| away Thursday, November 16 | #1 South Carolina | Columbia, S.C. | 7:00 PM | L, 40 - 109 | |
| home Sunday, November 19 | Longwood | Clemson, S.C. (Littlejohn Coliseum) | 3:30 PM | W, 102-63 | |
| neutral Friday, November 24 | #25 Mississippi State | Houston, Texas | 7:00 PM | L, 78 - 81 | |
| neutral Saturday, November 25 | Tulsa | Houston, Texas | 7:00 PM | L, 64 - 74 | |
| neutral Sunday, November 26 | Arkansas - Pine Bluff | Houston, Texas | 4:15 PM | W, 92 - 66 | |
| away Thursday, November 30 | Auburn | Auburn, Ala. | 9:00 PM | L, 53 - 83 | |
| home Thursday, December 07 | Duke * | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | W, 80 - 64 | |
| home Saturday, December 16 | Georgia State | Clemson, S.C. (Littlejohn Coliseum) | 2:00 PM | L, 72 - 78 | |
| home Tuesday, December 19 | Air Force | Clemson, S.C. (Littlejohn Coliseum) | 1:00 PM | W, 70-54 | |
| home Friday, December 22 | ETSU | Clemson, S.C. (Littlejohn Coliseum) | 2:00 PM | W, 73 - 50 | |
| away Sunday, December 31 | #24 North Carolina * | Chapel Hill, N.C. | 12:00 PM | L, 76 - 82 | |
| home Sunday, January 07 | #22 Florida State * | Clemson, S.C. (Littlejohn Coliseum) | 4:00 PM | L, 72 - 78 | |
| away Thursday, January 11 | Georgia Tech * | Atlanta, GA | 7:00 PM | L, 62 - 70 | |
| away Sunday, January 14 | Syracuse * | Syracuse, N.Y. | 2:00 PM | L, 82 - 83 | |
| home Thursday, January 18 | #13 Louisville * | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | L, 64-81 | |
| away Sunday, January 21 | #14 Virginia Tech * | Blacksburg, VA | 12:00 PM | L, 62 - 74 | |
| home Thursday, January 25 | #7 NC State * | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | L, 49-71 | |
| home Sunday, January 28 | Wake Forest * | Clemson, S.C. (Littlejohn Coliseum) | 6:00 PM | W, 73-59 | |
| home Thursday, February 01 | Boston College * | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | W, 65-55 | |
| away Sunday, February 04 | Virginia * | Charlottesville, VA | 4:00 PM | W, 75-69 | |
| away Thursday, February 08 | Miami * | Miami, FL | 6:00 PM | L (OT), 72 - 75 | |
| home Thursday, February 15 | Georgia Tech * | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | L, 63 - 64 | |
| home Sunday, February 18 | Pittsburgh * | Clemson, S.C. (Littlejohn Coliseum) | 12:00 PM | L, 57 - 72 | |
| away Thursday, February 22 | #19 Notre Dame * | South Bend, IN | 7:00 PM | L, 47 - 74 | |
| home Sunday, February 25 | Miami * | Clemson, S.C. (Littlejohn Coliseum) | 2:00 PM | L, 50 - 56 | |
| away Thursday, February 29 | Wake Forest * | Winston-Salem, N.C. | 6:00 PM | W, 68 - 64 | |
| away Sunday, March 03 | Florida State * | Tallahassee, FL | 4:00 PM | L (OT), 79 - 82 | |
| neutral Wednesday, March 06 | No. 13 Boston College | Greensboro, N.C. | 1:00 PM | L, 72 - 85 | |
