| home Wednesday, November 01 | Newberry College (Exhibition) | Littlejohn Coliseum | 7:00 PM | W, 90 - 39 | |
| home Monday, November 06 | Winthrop | Littlejohn Coliseum | 7:00 PM | W, 78 - 56 | |
| neutral Friday, November 10 | UAB | Asheville, N.C. (Harrah's Cherokee Center) | 9:30 PM | W, 77 - 76 | |
| neutral Sunday, November 12 | Davidson | Asheville, N.C. (Harrah's Cherokee Center) | 3:00 PM | W, 68 - 65 | |
| home Sunday, November 19 | Boise State | Littlejohn Coliseum | 1:00 PM | W, 85 - 68 | |
| home Friday, November 24 | Alcorn State | Littlejohn Coliseum | 8:00 PM | W, 90 - 69 | |
| away Tuesday, November 28 | Alabama | Tuscaloosa, Ala. (Coleman Coliseum) | 9:30 PM | W, 85 - 77 | |
| away Sunday, December 03 | Pittsburgh * | Pittsburgh, Pa. (Petersen Events Center) | 2:00 PM | W, 79 - 70 | |
| home Wednesday, December 06 | South Carolina | Littlejohn Coliseum | 8:00 PM | W, 72 - 67 | |
| neutral Saturday, December 09 | TCU | Toronto, Ontario, Canada (Coca-Cola Coliseum) | 4:00 PM | W, 74 - 66 | |
| away Saturday, December 16 | Memphis | Memphis, Tenn. (FedExForum) | 3:00 PM | L, 77 - 79 | |
| home Friday, December 22 | Queens | Littlejohn Coliseum | 6:00 PM | W, 109 - 79 | |
| home Friday, December 29 | Radford | Littlejohn Coliseum | 7:00 PM | W, 93 - 58 | |
| away Wednesday, January 03 | Miami (Fla.) * | Coral Gables, Fla. (Watsco Center) | 8:00 PM | L, 82 - 95 | |
| home Saturday, January 06 | North Carolina * | Littlejohn Coliseum | 12:00 PM | L, 55 - 65 | |
| away Wednesday, January 10 | Virginia Tech * | Blacksburg, Va. (Cassell Coliseum) | 7:00 PM | L, 72 - 87 | |
| home Saturday, January 13 | Boston College * | Littlejohn Coliseum | 3:00 PM | W, 89 - 78 | |
| home Tuesday, January 16 | Georgia Tech * | Littlejohn Coliseum | 9:00 PM | L (2OT), 90 - 93 | |
| away Saturday, January 20 | Florida State * | Tallahassee, Fla. (Donald L. Tucker Center) | 4:00 PM | W, 78 - 67 | |
| away Saturday, January 27 | Duke * | Durham, N.C. (Cameron Indoor Stadium) | 4:00 PM | L, 71 - 72 | |
| home Tuesday, January 30 | Louisville * | Littlejohn Coliseum | 9:00 PM | W, 70 - 64 | |
| home Saturday, February 03 | Virginia * | Littlejohn Coliseum | 2:00 PM | L, 65 - 66 | |
| away Tuesday, February 06 | North Carolina * | Chapel Hill, N.C. (Dean E. Smith Center) | 7:00 PM | W, 80 - 76 | |
| away Saturday, February 10 | Syracuse * | Syracuse, N.Y. (JMA Wireless Dome) | 12:00 PM | W, 77 - 68 | |
| home Wednesday, February 14 | Miami (Fla.) * | Littlejohn Coliseum | 7:00 PM | W, 77 - 60 | |
| home Saturday, February 17 | NC State * | Littlejohn Coliseum | 7:45 PM | L, 78 - 77 | |
| away Wednesday, February 21 | Georgia Tech * | Atlanta, Ga. (McCamish Pavilion) | 7:00 PM | W, 81 - 57 | |
| home Saturday, February 24 | Florida State * | Littlejohn Coliseum | 7:45 PM | W, 74 - 63 | |
| home Tuesday, February 27 | Pittsburgh * | Littlejohn Colisem | 7:00 PM | W, 69 - 62 | |
| away Saturday, March 02 | Notre Dame * | Notre Dame, Ind. (Purcell Pavilion) | 7:45 PM | L, 62 - 69 | |
| home Tuesday, March 05 | Syracuse * | Littlejohn Coliseum | 7:00 PM | W, 90 - 75 | |
| away Saturday, March 09 | Wake Forest * | Winston-Salem, N.C. (LJVM Coliseum) | 6:00 PM | L, 76 - 81 | |
| neutral Wednesday, March 13 | Boston College | Washington, D.C. (Capital One Arena) | 9:30 PM | L, 55 - 76 | |
| neutral Friday, March 22 | No. 11 New Mexico | FedEx Forum • Memphis, Tenn. | 6:10 PM | W, 77 - 56 | |
| neutral Sunday, March 24 | No. 3 Baylor | FedEx Forum • Memphis, Tenn. | 6:10 PM | W, 72 - 64 | |
| neutral Thursday, March 28 | No. 2 Arizona | Crypto.com Arena • Los Angeles, Calif. | 7:09 PM | W, 77 - 72 | |
| neutral Saturday, March 30 | No. 4 Alabama | Crypto.com Arena • Los Angeles, Calif. | 8:49 PM | L, 82 - 89 | |
