Duke 
Florida State 
Louisville 
Furman 
South Carolina 
LSU 
Troy 
Georgia Tech 
Syracuse 
North Carolina 
Boston College 
SMU 
Clemson leads 58-35-4
All Games at Clemson: Clemson leads 12-7-1All Games in Memorial Stadium: Clemson leads 12-7-1All Games at South Carolina: Clemson leads 46-28-3Games in William-Brice Stadium: Clemson leads 27-16-2Tommy Bowden vs. South Carolina: 1-0Lou Holtz vs. Clemson: 4-1Last Clemson Win: 31-21 at USC in 1999Last South Carolina Win: 34-31 at Clemson in 1996Last South Carolina Win at South Carolina: 20-7 in 1987Longest Clemson Streak: 7 (1934-1940)Longest USC Streak: 4 (1951-1954)Games Over Last 10 Years: Clemson leads 7-3-0Current Streak: Clemson has won three in a row, six in a row in ColumbiaLargest Clemson Win: 51-0, 1900Largest USC Win: 56-20, 1975
| When Clemson Played South Carolina | ||||
| Clemson | USC | |||
| Year | Was | Was | Site | Outcome |
| 1896 | 1-0-0 | 1st Game | A | USC, 12-6 |
| 1897 | 1-2-0 | 1st Game | A | Clemson, 18-6 |
| 1898 | 1-1-0 | 1-0-0 | A | Clemson, 24-0 |
| 1899 | 2-0-0 | 1-0-0 | A | Clemson, 34-0 |
| 1900 | 2-0-0 | 1-1-0 | A | Clemson, 51-0 |
| 1902 | 3-0-0 | 3-0-0 | A | USC, 12-6 |
| 1909 | 3-2-0 | 1-3-0 | A | Clemson, 6-0 |
| 1910 | 3-2-0 | 4-0-0 | A | Clemson, 24-0 |
| 1911 | 1-2-0 | 1-1-1 | A | Clemson, 27-0 |
| 1912 | 3-1-0 | 2-2-0 | A | USC, 22-7 |
| 1913 | 1-2-0 | 1-2-0 | A | Clemson, 32-0 |
| 1914 | 1-2-1 | 1-4-1 | A | Clemson, 29-6 |
| 1915 | 2-2-1 | 3-0-0 | A | Tie, 0-0 |
| 1916 | 1-3-0 | 2-3-0 | A | Clemson, 27-0 |
| 1917 | 2-1-0 | 1-1-0 | A | Clemson, 21-13 |
| 1918 | 1-1-0 | 1st Game | A | Clemson, 39-0 |
| 1919 | 3-2-0 | 1-3-0 | A | Clemson, 19-6 |
| 1920 | 3-2-1 | 2-2-0 | A | USC, 3-0 |
| 1921 | 1-2-1 | 3-01 | A | USC, 21-0 |
| 1922 | 2-1-0 | 3-1-0 | A | Clemson, 3-0 |
| 1923 | 1-1-1 | 2-2-0 | A | Clemson, 7-6 |
| 1924 | 2-1-0 | 3-1-0 | A | USC, 3-0 |
| 1925 | 0-3-0 | 3-1-0 | A | USC, 33-0 |
| 1926 | 2-2-0 | 3-1-0 | A | USC, 24-0 |
| 1927 | 2-1-1 | 3-1-0 | A | Clemson, 20-0 |
| 1928 | 5-0-0 | 5-0-0 | A | Clemson, 32-0 |
| 1929 | 5-0-0 | 3-1-0 | A | Clemson, 21-14 |
| 1930 | 5-0-0 | 3-1-0 | A | Clemson, 20-7 |
| 1931 | 1-2-1 | 1-2-0 | A | USC, 21-0 |
| 1932 | 2-2-0 | 3-1-0 | A | USC, 14-0 |
| 1933 | 1-1-2 | 1-2-0 | A | USC, 7-0 |
| 1934 | 1-3-0 | 3-1-0 | A | Clemson, 19-0 |
| 1935 | 3-1-0 | 2-3-0 | A | Clemson, 44-0 |
| 1936 | 2-3-0 | 3-2-0 | A | Clemson, 19-0 |
| 1937 | 1-3-0 | 2-2-1 | A | Clemson, 34-6 |
| 1938 | 2-1-1 | 3-2-0 | A | Clemson, 34-12 |
| 1939 | 2-1-0 | 1-3-0 | A | Clemson, 27-0 |
| 1940 | 4-0-0 | 0-2-0 | A | Clemson, 21-13 |
| 1941 | 4-0-0 | 1-1-1 | A | USC, 18-14 |
| 1942 | 1-2-1 | 0-2-1 | A | Clemson, 18-6 |
| 1943 | 1-2-0 | 2-1-0 | A | USC, 33-6 |
| 1944 | 2-1-0 | 1-1-1 | A | Clemson, 20-13 |
| 1945 | 3-1-0 | 2-2-0 | A | Tie, 0-0 |
| 1946 | 1-3-0 | 2-1-0 | A | USC, 26-14 |
| 1947 | 1-3-0 | 2-2-0 | A | USC, 21-19 |
| 1948 | 3-0-0 | 2-1-0 | A | Clemson, 13-7 |
| 1949 | 2-1-0 | 0-3-0 | A | USC, 27-13 |
| 1950 | 3-0-0 | 2-1-0 | A | Tie, 14-14 |
| 1951 | 3-1-0 | 2-2-0 | A | USC, 20-0 |
| 1952 | 1-3-0 | 2-2-0 | A | USC, 6-0 |
| 1953 | 1-2-1 | 3-1-0 | A | USC, 14-7 |
| 1954 | 2-2-0 | 2-1-0 | A | USC, 13-8 |
| 1955 | 3-1-0 | 2-2-0 | A | Clemson, 28-14 |
| 1956 | 3-0-1 | 4-1-0 | A | Clemson, 7-0 |
| 1957 | 2-2-0 | 3-1-0 | A | Clemson, 13-0 |
| 1958 | 4-0-0 | 2-2-0 | A | USC, 26-6 |
| 1959 | 3-1-0 | 3-1-0 | A | Clemson, 27-0 |
| 1960 | 4-3-0 | 1-5-0 | H | Clemson, 12-2 |
| 1961 | 3-4-0 | 2-5-0 | A | USC, 21-14 |
| 1962 | 5-4-0 | 4-4-1 | H | Clemson, 20-17 |
| 1963 | 4-4-1 | 1-7-1 | A | Clemson, 24-20 |
| 1964 | 3-6-0 | 2-5-2 | H | USC, 7-3 |
| 1965 | 5-4-0 | 4-5-0 | A | USC, 17-16 |
| 1966 | 5-4-0 | 1-8-0 | H | Clemson, 35-10 |
| 1967 | 5-4-0 | 5-4-0 | A | Clemson, 23-12 |
| 1968 | 4-4-1 | 3-6-0 | H | USC, 7-3 |
| 1969 | 4-5-0 | 6-3-0 | A | USC, 27-13 |
| 1970 | 3-7-0 | 3-6-1 | H | USC, 38-32 |
| 1971 | 4-6-0 | 6-4-0 | A | Clemson, 17-7 |
| 1972 | 3-7-0 | 4-6-0 | H | Clemson, 7-6 |
| 1973 | 5-5-0 | 6-4-0 | A | USC, 32-20 |
| 1974 | 6-4-0 | 4-6-0 | H | Clemson, 38-21 |
| 1975 | 2-8-0 | 6-4-0 | A | USC, 56-20 |
| 1976 | 2-6-2 | 6-4-0 | H | Clemson, 28-9 |
| 1977 | 7-2-1 | 5-5-0 | A | Clemson, 31-27 |
| 1978 | 9-1-0 | 5-4-1 | H | Clemson, 41-23 |
| 1979 | 8-2-0 | 7-3-0 | A | USC, 13-9 |
| 1980 | 5-5-0 | 8-2-0 | H | Clemson, 27-6 |
| 1981 | 10-0-0 | 6-4-0 | A | Clemson, 29-6 |
| 1982 | 7-1-1 | 4-6-0 | H | Clemson, 24-6 |
| 1983 | 8-1-1 | 5-5-0 | A | Clemson, 22-13 |
