| away Thursday, October 01 | South Carolina | Columbia, S.C. | 7:00 PM | W, 3 - 0 | |
| home Monday, October 05 | UAB | Clemson, S.C. || Historic Riggs Field | 6:00 PM | W, 2 - 0 | |
| away Friday, October 09 | UNC * | Chapel Hill, N.C. | 6:00 PM | L, 0 - 1 | |
| home Tuesday, October 13 | #1 Wake Forest * | Clemson, S.C. || Historic Riggs Field | 7:00 PM | W, 2 - 1 | |
| home Friday, October 16 | Duke * | Clemson, S.C. || Historic Riggs Field | 8:00 PM | W (2OT), 2 - 1 | |
| away Friday, October 23 | NC State * | Raleigh, N.C. || Dail Soccer Field/Track Complex | 8:00 PM | W, 1 - 0 | |
| home Tuesday, October 27 | #5 UNC * | Clemson, S.C. || Historic Riggs Field | 7:00 PM | T, 3 - 3 | |
| away Friday, October 30 | #2 Wake Forest * | Winston-Salem, N.C. || Spry Stadium | 5:00 PM | L, 0 - 2 | |
| neutral Sunday, November 15 | #5 Virginia Tech | Durham, N.C. | 12:00 PM | W, 4 - 1 | |
| neutral Wednesday, November 18 | Virginia | Chapel Hill, N.C. || Dorrance Field | 6:00 PM | W, 2 - 1 | |
| neutral Sunday, November 22 | #1 Pittsburgh | Cary, N.C. || WakeMed Soccer Park | 12:00 PM | W, 2 - 1 | |
| neutral Saturday, February 20 | North Carolina (exhib.) | Pineville, N.C. || CSA OrthoCarolina Sportsplex | 4:00 PM | L, 0 - 1 | |
| home Sunday, March 07 | Syracuse * | Clemson, S.C. || Historic Riggs Field | 5:00 PM | W, 3 - 1 | |
| away Saturday, March 13 | #21 Virginia Tech * | Blacksburg, Va. | 5:00 PM | W (2OT), 1 - 0 | |
| home Saturday, March 20 | NC State * | Clemson, S.C. || Historic Riggs Field | 7:00 PM | W, 1 - 0 | |
| away Saturday, March 27 | Boston College * | Newton, Mass. | 1:00 PM | W, 3 - 2 | |
| home Friday, April 02 | #4 Wake Forest * | Clemson, S.C. || Historic Riggs Field | 7:00 PM | T, 0 - 0 | |
| away Friday, April 09 | Louisville * | Louisville, Ky. | 7:00 PM | L, 1 - 2 | |
| home Saturday, April 17 | #1 Pittsburgh | Clemson, S.C. || Historic Riggs Field | 7:00 PM | W, 2 - 0 | |
| neutral Sunday, May 02 | American | Winston-Salem, N.C. || Spry Stadium | 4:00 PM | W, 2 - 1 | |
| neutral Thursday, May 06 | Marshall | Cary, N.C. || WakeMed Field #2 | 3:00 PM | T, 1 - 1 (Marshall Advances on PKs, 7-6) | |
