| home Tuesday, October 29 | Lander | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | L, 72-74 | |
| home Wednesday, November 06 | Furman | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | W, 77 - 71 | |
| home Saturday, November 09 | Navy | Clemson, S.C. (Littlejohn Coliseum) | 1:00 PM | L, 52 - 65 | |
| home Tuesday, November 12 | Alabama | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | L, 54 - 67 | |
| home Monday, November 18 | Alabama State | Clemson, S.C. (Littlejohn Coliseum) | 11:00 AM | W, 76 - 43 | |
| away Thursday, November 21 | Penn State | University Park, Pa. (Bryce Jordan Center) | 7:00 PM | L, 55 - 68 | |
| home Sunday, November 24 | #5/6 South Carolina | Clemson, S.C. (Littlejohn Coliseum) | 2:00 PM | L, 48 - 84 | |
| neutral Friday, November 29 | #9/10 Maryland | Daytona Beach, Fla. | 5:45 PM | L, 44 - 63 | |
| neutral Saturday, November 30 | Alcorn State | Daytona Beach, Fla. | 8:00 PM | W, 77 - 46 | |
| away Wednesday, December 04 | Iowa | Iowa City, Iowa (Carver-Hawkeye Arena) | 9:00 PM | L, 60 - 74 | |
| home Sunday, December 08 | Florida State * | Clemson, S.C. (Littlejohn Coliseum) | 12:00 PM | L, 64 - 81 | |
| away Sunday, December 15 | Mercer | Macon, Ga. (Hawkins Arena) | 2:00 PM | W, 65 - 61 | |
| home Friday, December 20 | NC A&T | Clemson, S.C. (Littlejohn Coliseum) | 2:00 PM | L, 74 - 82 | |
| away Sunday, December 29 | Notre Dame * | Notre Dame, Ind. (Joyce Center) | 4:00 PM | W, 71 - 55 | |
| home Thursday, January 02 | Louisville * | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | L, 50 - 75 | |
| away Thursday, January 09 | Wake Forest * | Winston-Salem, N.C. (Lawrence Joel Memorial Coliseum) | 7:00 PM | L, 58 - 63 | |
| away Sunday, January 12 | Georgia Tech * | Atlanta, Ga. (McCamish Pavilion) | 2:00 PM | L, 47 - 49 | |
| home Thursday, January 16 | Pittsburgh * | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | W (OT), 75 - 67 | |
| home Sunday, January 19 | Duke * | Clemson, S.C. (Littlejohn Coliseum) | 12:00 PM | W, 62 - 58 | |
| away Thursday, January 23 | Miami * | Miami, Fla. (Watsco Center) | 6:00 PM | L, 64 - 68 | |
| away Sunday, January 26 | Virginia Tech * | Blacksburg, Va. (Cassell Coliseum) | 1:00 PM | L, 50 - 71 | |
| home Thursday, January 30 | NC State * | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | L, 60 - 79 | |
| away Sunday, February 02 | North Carolina * | Chapel Hill, N.C. (Carmichael Arena) | 2:00 PM | L, 72 - 86 | |
| away Thursday, February 06 | Virginia * | Charlottesville, Va. (John Paul Jones Arena) | 7:00 PM | L, 54 - 70 | |
| home Sunday, February 09 | Boston College * | Clemson, S.C. (Littlejohn Coliseum) | 12:00 PM | L, 68 - 70 | |
| home Thursday, February 13 | Wake Forest * | Clemson, S.C. (Littlejohn Coliseum) | 7:00 PM | L, 52 - 66 | |
| home Sunday, February 16 | Miami * | Clemson, S.C. (Littlejohn Coliseum) | 1:00 PM | L, 48 - 63 | |
| away Thursday, February 20 | Syracuse * | Syracuse, N.Y. (Carrier Dome) | 6:00 PM | L, 46 - 59 | |
| away Thursday, February 27 | Florida State * | Tallahassee, Fla. (Donald L. Tucker Center) | 7:00 PM | L, 54 - 81 | |
| home Sunday, March 01 | Georgia Tech * | Clemson, S.C. (Littlejohn Coliseum) | 1:00 PM | L, 44 - 56 | |
| neutral Wednesday, March 04 | Miami | Greensboro, N.C. | 6:30 PM | W, 71 - 56 | |
| neutral Thursday, March 05 | Boston College | Greensboro, N.C. | 8:00 PM | L, 73 - 85 | |
