| home Monday, November 01 | Georgia Southwestern State (Exhibition) | Littlejohn Coliseum | 7:00 PM | W, 77 - 51 | |
| home Tuesday, November 09 | Presbyterian | Littlejohn Coliseum | 7:00 PM | W, 64 - 53 | |
| home Friday, November 12 | Wofford | Littlejohn Coliseum | 7:00 PM | W, 76 - 68 | |
| home Monday, November 15 | Bryant | Littlejohn Coliseum | 7:00 PM | W, 93 - 70 | |
| neutral Thursday, November 18 | Temple | Charleston, S.C. (TD Arena) | 4:00 PM | W, 75 - 48 | |
| neutral Friday, November 19 | St. Bonaventure | Charleston, S.C. (TD Arena) | 2:30 PM | L, 65 - 68 | |
| neutral Sunday, November 21 | West Virginia | Charleston, S.C. (TD Arena) | 5:00 PM | L, 59 - 66 | |
| home Friday, November 26 | Charleston Southern | Littlejohn Coliseum | 2:00 PM | W, 91 - 59 | |
| away Tuesday, November 30 | Rutgers | Piscataway, N.J. (Jersey Mikes Arena) | 9:00 PM | L, 64 - 74 | |
| away Saturday, December 04 | Miami * | Coral Gables, Fla. (Watsco Center) | 12:00 PM | L, 75 - 80 | |
| neutral Saturday, December 11 | Drake | Atlanta, Ga. (State Farm Arena) | 2:00 PM | W (OT), 90 - 80 | |
| home Tuesday, December 14 | Miami (Ohio) | Littlejohn Coliseum | 7:00 PM | W, 89 - 76 | |
| home Saturday, December 18 | South Carolina | Littlejohn Coliseum | 6:00 PM | W, 70 - 56 | |
| away Wednesday, December 22 | Virginia * | Charlottesville, Va. (John Paul Jones Arena) | 7:00 PM | W, 67 - 50 | |
| home Wednesday, December 29 | Duke * | Littlejohn Coliseum | 2:00 PM | PPD. | |
| home Tuesday, January 04 | Virginia * | Littlejohn Coliseum | 9:00 PM | L, 65 - 75 | |
| away Saturday, January 08 | NC State * | Raleigh, N.C. (PNC Arena) | 12:00 PM | W, 70 - 65 | |
| away Wednesday, January 12 | Notre Dame * | Notre Dame, Ind. (Joyce Center) | 7:00 PM | L, 56 - 72 | |
| home Saturday, January 15 | Boston College * | Littlejohn Coliseum | 6:30 PM | L, 68 - 70 | |
| away Tuesday, January 18 | Syracuse * | Syracuse, N.Y. (Carrier Dome) | 9:00 PM | L, 78 - 91 | |
| home Saturday, January 22 | Pittsburgh * | Littlejohn Coliseum | 6:00 PM | W, 75 - 48 | |
| away Tuesday, January 25 | Duke * | Durham, N.C. (Cameron Indoor Stadium) | 7:00 PM | L, 69 - 71 | |
| home Wednesday, February 02 | Florida State * | Littlejohn Coliseum | 7:00 PM | W, 75 - 69 | |
| away Saturday, February 05 | Georgia Tech * | Atlanta, Ga. (McCamish Pavilion) | 2:00 PM | L, 64 - 69 | |
| home Tuesday, February 08 | North Carolina * | Littlejohn Coliseum | 6:00 PM | L, 77 - 79 | |
| home Thursday, February 10 | Duke * | Littlejohn Coliseum | 8:00 PM | L, 64 - 82 | |
| home Saturday, February 12 | Notre Dame * | Littlejohn Coliseum | 7:00 PM | L, 61 - 76 | |
| away Tuesday, February 15 | Florida State * | Tallahassee, Fla. (Donald L. Tucker Civic Center) | 7:00 PM | L, 80 - 81 | |
| away Saturday, February 19 | Louisville * | Louisville, Ky. (KFC Yum! Center) | 3:00 PM | L, 61 - 70 | |
| home Wednesday, February 23 | Wake Forest * | Littlejohn Coliseum | 7:00 PM | W, 80 - 69 | |
| away Saturday, February 26 | Boston College * | Chestnut Hill, Mass. (Conte Forum) | 3:00 PM | W, 70 - 60 | |
| home Wednesday, March 02 | Georgia Tech * | Littlejohn Coliseum | 7:00 PM | W, 68 - 65 | |
| home Saturday, March 05 | Virginia Tech * | Littlejohn Coliseum | 2:00 PM | W, 63 - 59 | |
| neutral Tuesday, March 08 | NC State | Brooklyn, N.Y. (Barclays Center) | 4:30 PM | W, 70 - 64 | |
| neutral Wednesday, March 09 | Hokies | Brooklyn, N.Y. (Barclays Center) | 7:00 PM | (OT), 75 - 76 | |
